This attention to detail extends to our carefully curated selection of CBD topical products. It’s incredibly important to us that you feel confident in your next CBD purchase, and if you’re ever unsure about anything related to CBD, our friendly and knowledgeable support team are only a click away. Browse our range of CBD salves, ointments, and other topicals, or get in touch if you have any questions.
My grandma has advanced rheumatoid arthritis and osteoarthritis - debilitating pain and inflammation. She's on the 4th failed infusion. Nothing was working to control her pain and inflammation. I purchased the 1000mg mint CBD and the topical. I put the topical on her knees, ankles, shoulders, back, hips, and then gave her 15 1000mg drops. She instantly felt relief with the topical. She said it was a cooling pain relief. The topical smells really good.
The first step to finding your correct CBD dosage is getting as much information as you can about the product you’re using. What is the concentration of CBD? Are there third-party lab tests that can confirm that? The CBD industry is still mainly a grassroots therapeutic movement, and as such, largely unregulated. Concentration and purity levels can differ greatly depending on the manufacturing process.  

All I am seeing on this site is this brand is fantastic and that brand is fantastic! I don’t think I could trust any of these with the exception of one. I believe the only way to actually get good quality CBD is from a state licensed dispensary. Everyone else just wants to make a quick buck by jumping on the hype that it is now legal in all 50 states! I have cancer and herniated discs and fibromyalgia, asthma, PTSD, CFS severe anxiety, etc and will be starting radiation shortly. My pain right now is off the charts. I am afraid of most medications and pretty much will not take too many things. So when I get the CBD oil I will do it in front of a doctor to make sure of allergies. It will have to be of high quality and something that will not get me high! The fear of taking something from just any online distributor doesn’t ensure quality. If anyone out there can tell me with the most positive knowledge that a product is what it is then you can let me know. Any recommendations?
My husband has RSD and we are considering CBD oil -= I would ask at Hempmed because the spray won't have enough in it. Our dgt';s friend has ovarian cancer and it is shrinking her tumors but the spray would never have been enough. I would get CBD oil and check with Hempmeds to see what they suggest. It isn't cheap but it does work. LOW dose Naltrexone about 4.5 mg is very helpful for RSD and is usually used for getting people off of drugs but is working on turning off the glial cells that surround the nerve that is causing the nerve to scream in pain. We are also using PeaPure that is out of the Netherlands and we are seeing a response, even though small. His other leg touched the painful leg without causing more severe pain. That is progress. We also are using Poison Ivy Cream through Meadowlake Farms that has helped the burning surface pain. Change your diet and get rid of Gluten and Sugar, anything that causes inflammation. This is to allow your own body to work. Absolutely do not use any pain killers as it will turn up your pain. all the Hydrocodone, etc causes neural inflammation and so it will keep cascading higher your pain. Hope this is helpful. Mary
Sagely Naturals tests its products three times: the raw cannabidiol is evaluated by extractors, then by another third party lab. Finally, when the company receives the final product, Sagely randomly selects bottles to test for the third and final time. These tests ensure that the product is devoid of GMOs, solvents, chemicals, heavy metals, pesticides, herbicides, and THC.
CBD (Cannabidiol) is a prominent, non-psychoactive cannabinoid found in hemp oil. It is typically extracted from industrial hemp plants that are naturally high in CBD and other phytochemicals. It is the most prevalent of over 80 different cannabinoids found in natural hemp. It is commonly used for its therapeutic properties. Cannabidiol is responsible for a wide-range of positive health benefits through its interaction with the body's own endocannabinoid system.
In the early days of cannabis culture—we’re talking the 1960s, 70s, and 80s, before CBD isolate was a gleam in some stoner chemist’s eye—you pretty much only had two ways to consume your chronic: smoke it or bake it in a brownie. We know this was a LONG time ago—heck, the word “chronic” still only had one definition (and it had nothing to do with pot), but it’s important to understand the past in order to appreciate the present.
Tammy et al, Through trial and error you will find a correct dosage. Try 50 mg daily....25 each 2x daily....if no results up the dosage until it works for you. Remember, there has never been a death from marijuana or CBD use. You might want to try a tincture or rub with CBD and THC. You won't get the psych high from it. Helps my friend with PArkinsons tremors. She takes 50mg of tincture and uses the rub morning and night. It is a miracle for arthritis. Good luck
Due to its wide variety of medical benefits, CBD is used to treat a number of common conditions, including chronic pain, inflammation, seizures, insomnia, spasms, multiple sclerosis, and mental disorders such as anxiety and depression. As a topical agent, CBD oil can be directly applied to certain areas of the body as an effective means of relieving pain and soreness, reducing inflammation, and soothing inflammatory skin conditions such as psoriasis, dermatitis, and eczema.
As a consumer, you can look at the manufacturer's website to see whether they batch-test their products, or ask them directly. You could also send a sample of your CBD oil to a testing facility yourself, something Bonn-Miller says he would do if he were trying to treat someone with a severe issue such as epilepsy. Testing can also determine whether the product contains pesticides, heavy metals, or other toxins.

Hi Colleen, it's almost a year later and I'm wondering how you're doing. I'm experiencing a recurrence of Stage 3 ovarian, originally diagnosed in 2011. I've decided to get some chemo, not sold on another 6 cycles though. As a new MMJ patient, I'm still going to go through with Rick Simpson Oil (THC+CBD,) and I just joined a program with my local dispensary to get CBD capsules for $2 each when I order them at least 30 at a time. I hope you're doing well!! I'm off to do more research on dosing. **NOTE: If you have ANY experience with CBD treatment of ovarian cancer, PLEASE respond. Thank you!!

The views expressed in this article are intended to spark conversation and highlight alternative studies and is for information purposes only. We are not here to diagnose or treat any health or medical conditions, nor should this be relied upon as a substitute for professional medical advice, diagnosis or treatment, even if it features the advice of health experts, medical practitioners or physicians. When making any lifestyle or health changes, consult your primary care physician. The views expressed in this article are the views of the author and do not necessarily represent the views of Organic Authority, Inc.
Jump up ^ Devinsky, Orrin; Cilio, Maria Roberta; Cross, Helen; Fernandez-Ruiz, Javier; French, Jacqueline; Hill, Charlotte; Katz, Russell; Di Marzo, Vincenzo; Jutras-Aswad, Didier; Notcutt, William George; Martinez-Orgado, Jose; Robson, Philip J.; Rohrback, Brian G.; Thiele, Elizabeth; Whalley, Benjamin; Friedman, Daniel (22 May 2014). "Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders". Epilepsia. 55 (6): 791–802. doi:10.1111/epi.12631. PMC 4707667. PMID 24854329.

Cannabis has been used medicinally for centuries, as a sleep aid, a pain and nausea reducer, to relieve anxiety and other mood problems. In the mid-1960s, scientists identified the first cannabinoid. Since then, scientists have gone on to identify more than 80 individual cannabinoids and continue to investigate them for their potential symptom-relieving and disease-fighting abilities.


CBD’s antipsychotic properties make it a viable alternative to pharmaceuticals for schizophrenic patients.  Generally, CBD is a great alternative for pharmaceuticals used to treat a host of diseases.  This is a big deal since pharmaceuticals are responsible for the epidemic of prescription drug abuse ripping through our country and the vast amount of side effects either debilitating or killing pharmaceutical patients.


It used to be that recreational cannabis users kept their habit on the DL, but now it seems that everyone is tuned into the magic of CBD, from your elderly neighbor using it for glaucoma to the woman in your book group using it for chronic pain relief to the folks at the dog park helping Rusty tone down his anxiety. But what is this magic substance, and more importantly, what can it do for you?
CBD isolate is derived from the hemp plant via various processes. These processes make extraction and isolation of CBD possible. Typically, the process of producing CBD isolate starts with growing hemp organically. This is not the cannabis strain that gets users high. The isolate is produced from a commercial-grade, industrial hemp. Basically, this is the cannabis that is grown to produce maximum biomass. It’s important to note that hemp is different from marijuana that is found in the streets and used by people that want to get high. However, both hemp and marijuana are technically similar plants. The only difference is that hemp has THC in low amounts and CBD in high amounts.

Everything you need to know about marijuana (cannabis) Marijuana, or cannabis, is the most commonly used illicit drug in the world. It alters the mood and affects nearly every organ in the body. With at least 120 active compounds, marijuana may have health benefits as well as risks. We describe these, addiction, and withdrawal. Learn more about cannabis here. Read now
I suffer fr migraines. Currently having Botox injections every three months for the last three years. This has helped went fr 24 to 30 migraines a month to 6 to 8 , now I'm back up to 14 to 20 a month. My doctor thought CBD oil might help. I have also started having anxiety attacks for a year now. I'm really confused with the dosages. Any thoughts would b helpful
There are two preventative procedures you should be taking if you want to keep your skin as youthful for as long as possible: wear sunscreen and wear anti-aging cream at night. Unfortunately, I couldn’t source a reputable sunscreen with CBD, so you’ll have to trust me on the face cream, instead. This organic hemp CBD—sourced from Colorado—and vitamin E oil-enriched formula is too rich for daytime use (unless you have very dry skin and you don’t live in a humid climate), but it’s the perfect luxe treatment to massage into your face and neck before bed every night. After a week of wearing this cream every night, I, a very cystic acne-prone person, did not have any breakouts and had noticeably softer skin in the morning.

Many people take CBD oil for joint pain or even muscle soreness, but most would suggest that they are not as soothing or fast-acting as applying a topical CBD cream directly to the site of pain or soreness. Using a topical CBD cream for muscle soreness is also effective due to the simple mechanical effects of massaging. When you massage sore muscles, what you’re actually doing is stimulating the fibers in the contractile tissue to engage in capillary action; in other words, the fibers are actively exchanging expended blood and replenishing themselves with a new, freshly-oxygenated supply from arterioles.

We are staunch advocates of CBD and its many, amazing, scientifically-backed uses. We are also staunch advocates of our patrons and their access to the highest quality, 100% organic CBD products around. Getting the information you need, the exact product you want, and a no hassle transaction with no attached shipping charges – that’s what we are all about.

Scientists have made a lot of progress in understanding how CBD produces its calming, pain-reducing, anti-inflammatory effects in the body—and there’s still more to learn. We know that CBD interacts with many different receptors, proteins, and other chemicals in the brain. These interactions create changes in the activity of neurotransmitters, hormones, and other cells throughout the brain and body. Through these interactions, CBD appears to be able to affect many of the body’s functions, from sleep-wake cycles and emotional regulation to inflammation, pain perception, and seizures.
This safe and carefully tested CBD for Pets Blend by Herbal Renewals is the ideal food supplement for your four-legged friend. Created using high-quality hemp oil and coconut oil, you can feel confident that you’re giving your pet the very best. Simply calculate the recommended serving size by your pet’s weight and add a few drops to their food, twice daily.

The benefits and effects of CBD in general (and CBD isolate specifically) go hand-in-hand. One of the major benefits of CBD is that it has no side effects (other than dry mouth, which is par for the course with marijuana products). It has been shown to interfere with liver enzymes that break down the ingredients in most drugs, so talk to your doctor before taking a product like CBD isolate.
As a representative with 2 companies that have CBD on the market and as a person with intractable pain and multple painful problems wirth my spine I can say that cbd does not work for everyone. It does nothing for me or for my mil who has a cancer like growth impeding her ability to swallow and has undergone radiation to shrink it. Everyone has a chemistry that’s personal to them for some it helps but for many it does not. With that in mind it’s a 50/50 chance of it helping and until you come out your pocket you’ll never know. Buyer beware.
The statements and products referred to throughout this site have not been evaluated by the FDA. They are not intended to diagnose, treat, cure or prevent any disease or condition. If you have a health condition or concern, consult a physician or your health care provider. Always consult a medical doctor before modifying your diet, using any new product, drug, supplement, or doing new exercises. We recommend you educate yourselves on the scientific / nutritional facts.
I wanted to tell people here that CBD has been very effective for my anxiety, and helps with insomnia. For me, it was a cumulative effect, after a week of one dropper of oil, I can sleep very well at night. I feel like I am not polluting my body with commercial pharmaceuticals. I wish everyone here the best, and hope it works for you as well as it has for me.
One thing to keep in mind when creating your own Cannabidiol-infused oils, be sure to accurately calculate the potency of your individual servings. Because it is over 99% pure, each milligram of CBD isolate represents a milligram of active CBD. Each 1 gram jar of RSHO™ CBD isolate contains 990 mg of Cannabidiol, which can be broken down into specific servings of any size. This gives you exact control over how you choose to add CBD to your system.
The increased popularity of CBD has led many users to raise questions about the methods of extracting and administering CBD. The main question is which form provides the most effective range of medical benefits for the user. The two most common forms of extracted CBD found in stores are full-spectrum (whole-plant extract) and pure CBD isolate. Most users prefer the full-spectrum option. As CBD's usefulness for medical purposes has become more accepted over the years, new methods of administering it have continued to evolve.
The benefits and effects of CBD in general (and CBD isolate specifically) go hand-in-hand. One of the major benefits of CBD is that it has no side effects (other than dry mouth, which is par for the course with marijuana products). It has been shown to interfere with liver enzymes that break down the ingredients in most drugs, so talk to your doctor before taking a product like CBD isolate.
CBD E-Liquid/Vape Cartridges: Vaping is excellent for people looking for an immediate response, as inhalation is the fastest way to deliver CBDs to your brain and body. To use vape simply exhale gently the air from your lungs then inhale through the mouthpiece slowly for 3 seconds. Then fill your lungs the rest of the way with additional breath and hold for a few seconds, exhaling when ready. There are pre-filled, cost-effective vape pens and cartridges available as well as more expensive vaporizers that you can refill with CBD-infused e-liquid.
CBD Isolates/Concentrates: Anyone familiar with smoking hash or other cannabis concentrates like wax and BHO will be no stranger to this delivery method. Simply sprinkle some into a vaporizer or water pipe, ignite, inhale, and enjoy! We find that this option is useful for individuals looking to elevate their regular consumption of CBD-rich cannabis flowers or other smokable herbs.
Hemp is a bioaccumulator, meaning it is capable of absorbing both the good and the bad from the air, water, and soil in which it’s grown. This makes it all the more important to know that your CBD oil comes from organically grown hemp that can be tracked to its US-grown source. The last thing buyers want is for their CBD oil to have accumulated toxic substances such as pesticides, herbicides, or heavy metals. For decades, farmers have used pesticides to protect crops against insects, disease, and fungi – and have used herbicides to control weeds – but we’ve known for quite some time that chemicals used to harm other species can also be harmful to our own species. That’s one big reason behind the global push to go organic. People are starting to prioritize organic crops, whether you’re talking about fruits, vegetables, grains, legumes, nuts, livestock feed – even textiles like cotton, wool, and flax.
I have lower back pain with some arthritis and arthritis in my hands.ive recently tried CBD Oil. It really does work. I have the drops and ointment. They both work. Because of the back pain I never would have been able to go on a hike with my family. We had a lot of fun. And "No Pain", all day. I'm also Type 2 diabetic. Anxious to see what my A1C is next month. I'm a believer.
CBD powder, as you can imagine, is refined into extremely small grains of CBD until it reaches a powdery texture.  This is a great option if you are looking for an easy way to add CBD to cooking and baking recipes as it mixes right in with your other ingredients. CBD crystals, on the other hand, are larger, thicker, and will arrive in crystalline form. CBD crystals are used for dabbing.  Read more about CBD dabs.

The cannabis plant is filled with hundreds of different compounds, several of which have been studied for decades for their therapeutic benefits. The cannabis compounds that have captured the most scientific interest are known as cannabinoids. Cannabinoids are now used in treatment for a broad—and growing—range of conditions and symptoms, from sleep and pain, to anxiety and inflammation, to Parkinson’s disease and cancer.

I have idiopathic peripheral neuropathy ... the only thing they found that would work is lyrica. I picked up some CBD oil yesterday morning. I am prescribed to take 75 mg of lyrica 3x per day. I took one yesterday morning and have only used the CBD oil since. I bought the Koi brand, flavored, 250 MG. I used a full dropper yesterday late morning and a full dropper yesterday late afternoon. I used it once today (one full dropper) and I am amazingly pain free.
CBD has been producing a whole lot of buzz in the health community of late – but perhaps not the kind of buzz you might expect from a cannabinoid. Since you’re reading this, you’ve probably heard of CBD and its many touted benefits. From chronic pain to mental health, CBD has the potential to alleviate an astonishing number of ailments. But like many, you might be fuzzy on the details. Consider this your primer on all things CBD.
Even if you are comfortable with higher doses of CBD hemp oils, incorporating isolates into your health and wellness routine takes a little more skill. For example, if you regularly take twenty milligrams of CBD oil, have you considered what that translates into with an isolate? Remember, isolates are 99-percent pure, so twenty milligrams of an isolate is much stronger than twenty milligrams of an oil-based product.
Correct Answer: In the United States – all products should derived from organic hemp grown in the United States. Hemp grown in the European Union (EU) is acceptable (although less preferable than US-grown) ONLY if it is grown using organic methods and the company can prove the lack of pesticides, mold, and heavy metals through current test results (see below).
It used to be that recreational cannabis users kept their habit on the DL, but now it seems that everyone is tuned into the magic of CBD, from your elderly neighbor using it for glaucoma to the woman in your book group using it for chronic pain relief to the folks at the dog park helping Rusty tone down his anxiety. But what is this magic substance, and more importantly, what can it do for you?
In order to get CBD out of hemp, it must be extracted. CBD isolate is produced by using a bit of a more detailed extraction process of its own. CBD isolate extraction starts out like other extraction processes used to make CBD. Once the initial extraction takes place, concentrated CBD is still full of all the plant material contained in the hemp plant itself.

No, you *are no expert*–so you have no business making a diagnosis sight unseen. “Leaky gut” and “gluten sensitivity” (as opposed to celiac disease, which is legit) are among the trendy diagnoses du jour. You don’t know these folks’ diets, specific symptoms or official diagnoses. Don’t give me any blather about “Big Pharma,” “suppressing natural cures, “or the “medical industry conspiracy,” either. (“Suppression?” I get my CBD oil from an actual MD, with the approval of my oncologist).

Mike, what kind of breast cancer (invasive ductal, I presume)? How many of her lymph nodes were positive? How big was the primary tumor? Reason I ask is that in women with Stage I or IIA tumors that are estrogen-and progesterone-receptor-positive and HER2-negative (ER+/PR+/HER2-) with three or fewer positive lymph nodes, there is a genomic assay test on a sample of the tumor, called OncotypeDX, that will tell doctors whether chemo is necessary or would even work at all. Medicare covers that test 100%.That type of breast cancer mentioned above, which I had as Stage IA, is treated in postmenopausal women with anti-estrogen drugs called aromatase inhibitors(aka AIs: anastrazole, letrozole, or exemestane)which have as a side effect joint pain. CBD oil is effective for this joint pain it is not, I repeat, NOT a substitute for chemo, radiation or these anti-estrogen drugs.So don’t assume your mom’s cancer will require chemo; but if it does, CBD helps with those side effects as well. If she lives in a state where medical marijuana is legal, there are doctors who sub-specialize in certifying applications for a medical marijuana card, and in the interim before the card is issued can advise as to the appropriate dose of CBD oil (legal and over-the-counter in all 50 states). Some (though not most) medical oncologists will certify their own patients’ medical marijuana card applications so she need not seek out another doctor; and will advise the appropriate dose for her symptoms. Once she gets her card, the “budtenders” in the licensed dispensaries can advise her as to the right CBD product (with or without THC), strength, and dosage. If she lives in a state where recreational weed is legal, the “budtenders” in the marijuana shops can steer her to the right strength of CBD oil and the right dosage.
This article is right on. I have friends who have bought the cheaper CBD oil that really need the benefits and they didn’t get results. I looked at their labels and explained to them why. Quality CBD oil should NOT have olive oil in them… watered down. I use CBD oil for plantar fasciitis, bulging discs, arthritis and headaches. I’m a new person and wish everyone could experience this. Friend me on Facebook for more info or to purchase a quality product that will help you. I can help you get the answers you need and get a top CBD oil that does everything explained in this article. Plus, I can add you to a group that will support you through your CBD journey. Tap on my name at the top to go to my website to purchase a bottle. We have a 30 day empty bottle money back guarantee! This really is a top CBD oil with 3rd party testing, organic and non-GMO. THC free available, pet treats and relief creams too!
My mother has dementia/Alzheimers along with a broken knee that they will not repair do to her mental status. She is currently in a nursing home. I firmly believe her mental situation began with the over use of hydrocodone for over 30 years and was acerbated by the trauma of breaking and disconnecting her knee cap. Since weaning her off of her meds (still in progress) we have regained much of her consciousness. I want to try CBD to help in her recovery or to help slow down the disease. I cannot find a dosage recommendation plus the nursing home/doctor does not recommend it. I would need to give it to her when I am there visiting (about 3 - 4 times per week). Is there a recommended dosage for dementia/Alzheimers?
Also referred to as a full-spectrum extract, whole plant hemp extract contains all of the available benefits within the hemp material. By keeping all of the plant components, whole plant hemp extract benefits from the synergistic properties between the components. Scientists have found that plant components interact with one another to create an enhanced effect (compared to the component alone).
The following medications and other supplements may interact with CBD. Effects may include increasing or decreasing sleepiness and drowsiness, interfering with the effectiveness of the medications or supplements, and interfering with the condition that is being treated by the medication or supplement. These are lists of commonly used medications and supplements that have scientifically identified interactions with CBD. People who take these or any other medications and supplements should consult with a physician before beginning to use CBD.
It is for this reason that all the finished hemp goods that you see for sale in America, from food products to clothing to building materials, are part of an imported hemp industry that has surpassed $688 million annually. The size of this import industry is one of the major catalysts for hemp legalization in the U.S. As a renewable source of a range of products, hemp provides an exciting new step in American agriculture.
Bev, I am so sorry you are suffering with this condition it is horrible…… 🙁 Here is some other info. and recommendations Hubby has also used aloe vera pure clear get(not a lot of other stuff in with the aloe), and has also put coconut oil on his scalp and let it sit at night for about 20 minutes and then uses a fine tooth comb to get rid of some of the really dry flaky sores that are healing and then takes a shower and washes the oil out before we go to bed. He also had a prescription for topical stuff(forget what it was maybe clindomyacin?)that didn’t help. So what works best for him is to do the aloe vera, do the coconut oil, and keep his hair trimmed and thinned out. Depending on your hair length and thickness even though you are thinning due to the prob. I would suggest keeping hair shorter and have them thin it out with thinning shears overall, taking a multivitamin, Vit. D3 at least 2,000mg, and 10,000-20,000mcg biotin. I have thinning hair from going into to menopause but the biotin is really helping keeping it from all falling out. My hair was literally falling out in buckets before I started taking the Biotin and I think Vit. D3 has helped some too. I found out I had Vit. D3 shortage. You can get gel capsules of 10,000mcg Biotin so for awhile I took 2 a day. Aloe Vera is a anti-inflammatory so that can help, also don’t use any shampoos that have things like peppermint, rosemary, teatree oil, etc. which are irritants….. Write back eventually and let me know how you are doing…… 🙂

With the rapid growth of the CBD industry and constant advances in its technology, there are a lot of terms floating around that are unfamiliar, if not confusing, to many people. “Nano-Amplified CBD” is one of them. While the science and biological make-up of CBD is the subject of much research and scholarly articles, it can all be broken down into simple terms.


This is precisely why we here at Premium Jane do not advertise “CBD cream for arthritis for sale.” While it may be true that cannabidiol has displayed pain-relieving and anti-inflammatory effects in numerous scientific studies, will still maintain the notion that transparency is the most important thing we can offer to our customers. Those companies who blatantly urge you to buy CBD pain cream for arthritis are simply being deceptive, and not taking into consideration the current FDA status of cannabidiol as a medicine.
What if you could roll up your sleeves, tie on an apron and get in the kitchen/laboratory and create your own Cannabidiol mixtures and concoctions, in a Bill Nye meets Martha Stewart sort of way? It’s easy with CBD isolate recipes that you make or modify to help you create CBD isolate edibles. The convenience and versatility of CBD isolate hemp oil lets you do that and more!
CBD has been producing a whole lot of buzz in the health community of late – but perhaps not the kind of buzz you might expect from a cannabinoid. Since you’re reading this, you’ve probably heard of CBD and its many touted benefits. From chronic pain to mental health, CBD has the potential to alleviate an astonishing number of ailments. But like many, you might be fuzzy on the details. Consider this your primer on all things CBD.

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There’s a growing body of scientific evidence to support the use of topical CBD products to ease pain, inflammation, and the symptoms of arthritis. One study using rats found that topical CBD has “therapeutic potential for relief of arthritis pain-related behaviours and inflammation without evident side-effects.” More scientific research on humans is needed to confirm all of CBD’s benefits, but the initial research into topical use in humans is also promising.
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