Our bodies are thought to produce endocannabinoids by the billions every day. “We always thought the ‘runner’s high’ was due to the release of dopamine and endorphins. But now we know the euphoria is also from an endocannabinoid called anandamide,” its name derived from the Sanskrit word for bliss, says Joseph Maroon, M.D., clinical professor and vice chairman of neurosurgery at the University of Pittsburgh Medical Center. We produce these natural chemicals all day, but they fade quickly because enzymes pop up to destroy them. That’s where CBD comes in: By blocking these enzymes, CBD allows the beneficial compounds to linger. This is why Amanda Oliver, 31, a career consultant in Charleston, SC, pops a CBD gummy bear each night before bed. “I used to lie there tossing and turning as my mind raced from work projects to whether I had set the home alarm,” Oliver says. One piece of candy with 15 mg of CBD is enough to shut off her brain and facilitate sleep. She also swears by the CBD oil she takes at the height of her period, which she says quells her debilitating cramps.
If you’re just diving into the world of CBD, we recommend a starting serving size of two to three milligrams. From there, you can work your way up to 100 or even 200 milligrams, after you’ve taken the time to gradually observe how CBD affects your body and mind. Remember, you cannot overdose on CBD, and there are no reported side effects from using high concentrations. And if you’re using CBD pain relief cream for the first time, remember to apply directly to clean, dry skin.
Most human studies of CBD have been done on people who have seizures, and the FDA recently approved the first CBD-based drug, Epidiolex, for rare forms of epilepsy. Clinical trials for other conditions are promising, but tiny. In one Brazilian study published in 2011 of people with generalized social anxiety disorder, for example, taking a 600-mg dose of CBD (higher than a typical dose from a tincture) lessened discomfort more than a placebo, but only a dozen people were given the pill.
A quality CBD topical cream provides the advantage of being able to apply the active therapeutic hemp extract directly to the site of aggravation or discomfort. This is particularly useful for application to joint areas or superficial muscle tissue, as the cannabidiol compound will diffuse across the dermal layers directly to the site of pain and inflammation.

Like all of Dixie Botanicals® CBD products, our CBD Isolate is held to the same rigorous Triple Lab TestedTM standard. Accredited, independent labs carefully check the hemp oil three separate times throughout the manufacturing process to make sure its safety and potency standards are up to par. This guarantees you’re getting the CBD you expect and won’t be exposed to any mold, mildew, fungus, toxins, heavy metals, and residual solvents.
Cannabidiol can be taken into the body in multiple different ways, including by inhalation of cannabis smoke or vapor, as an aerosol spray into the cheek, and by mouth. It may be supplied as an oil containing only CBD as the active ingredient (no added THC or terpenes), a full-plant CBD-dominant hemp extract oil, capsules, dried cannabis, or as a prescription liquid solution.[1][3]
Plus CBD Oil™ products come in a variety of flavors and concentrations to suit your preferences. If you are considering CBD oil for your health, as with any supplement, we encourage you to speak with your physician and dive into the research to learn more about this promising phytonutrient. We at Plus CBD Oil™ are proud of our innovative selection of products.

CBD topicals include balms, salves, lotions, and oils that are infused with active cannabinoids and are applied to and absorbed directly through your skin. These cannabinoid-infused topicals have become a heavily demanded commodity in both the beauty and medicine worlds thanks to their soothing and rejuvenating effects. The popularity of topical CBD products has grown massively in recent years, with CBD and other cannabinoids making their way into various skin creams, lip balms, shampoos, and more. Choosing a topical can be overwhelming, so we’ve rounded up our ten best CBD products to get you started:


According to a growing body of research, CBD may play a role in the growth of new brain cells, a process known as neurogenesis. CBD is also widely recognized as having anti-oxidant and anti-inflammatory abilities, which make CBD a promising therapy for a wide range of conditions, from neurological disorders to autoimmune diseases to chronic pain and depression.

It sounds like the title of a children’s book, but like so much else that you learned in kindergarten, it’s true. Everyone’s body is different – but everyone’s endocannabinoid system is really unique. For reasons we don’t fully understand, receptors in the endocannabinoid system don’t respond predictably to cannabinoids from person to person. This lack of a predictable response makes standard dosing tricky.

Strength is also an extremely important consideration. Beginners may find that it’s easier to control dosage using a lower strength tincture. On the other hand, experienced CBD consumers know that high strength tinctures are more cost effective. Although stronger tinctures cost more, you get more CBD oil and other beneficial cannabinoids in each drop. Most CBD brands offer more than one option for strength.
Maintain a clear mind and active lifestyle with Endoca™ CBD hemp oil! - Hemp oil extracts have traditionally been used around the globe as medicine. A large body of evidence has indicated that the benefits of CBD hemp oil can relieve various ailments. Endoca maintains the biochemical equilibrium within the hemp plants to maximize the beneficial effects of its organic CBD oil.
In the United States, over three million people suffer from epilepsy – 470,000 of those people are children. Epilepsy is a disorder of the brain that causes seizures – of which there are over thirty different kinds, ranging from mild and infrequent to life-threatening. Not surprisingly, people with epilepsy face significant challenges – from the cost of healthcare to work limitations and social isolation.
This all serves to underline the importance of testing CBD extract for the various levels of active ingredients. If your homemade CBD extract contains a high amount of THC it could be illegal in your country and require you use either a different method of extraction, or more likely, the need to find a source of hemp that has lower THC. As more scientific literature emerges supporting the entourage effect, and increased benefits of full-spectrum CBD compared to CBD isolate, we can expect the manufacture and sale of CBD goods based around isolate to greatly reduce in the coming years.

Nano-Amplified CBD starts with the all-natural botanical concentrate that includes the cannabinoids and fatty acids found in hemp plants. Cannabidiol (CBD) is one of the more than 85 cannabinoids found in various concentrations throughout the different parts of the hemp plant, which is part of the Cannabiceae family. Cannabinoids are class of botanical chemical compounds that deliver an array benefits.
If you read the ingredient list, often everything in the jar is straight from mother earth. As long as that's indeed the case with the cream you have your eye on, the formula is immensely safe, chemically, says Gregory Gerdeman, Ph.D., neurophysiologist who researches cannabinoid biology and pharmacology at Eckerd College in Saint Petersburg, FL.. And since they're formulated to be topical—absorbing into the top layer of skin—and not transdermal—which would pass through the skin and into your bloodstream—there's no risk of getting high, Gerdeman explains. (P.S. Here's How Marijuana Affects Athletic Performance.)
Correct Answer: In the United States – all products should derived from organic hemp grown in the United States. Hemp grown in the European Union (EU) is acceptable (although less preferable than US-grown) ONLY if it is grown using organic methods and the company can prove the lack of pesticides, mold, and heavy metals through current test results (see below).
Scientists have made a lot of progress in understanding how CBD produces its calming, pain-reducing, anti-inflammatory effects in the body—and there’s still more to learn. We know that CBD interacts with many different receptors, proteins, and other chemicals in the brain. These interactions create changes in the activity of neurotransmitters, hormones, and other cells throughout the brain and body. Through these interactions, CBD appears to be able to affect many of the body’s functions, from sleep-wake cycles and emotional regulation to inflammation, pain perception, and seizures.
It’s a truism to state that pain is an inevitable part of life. And it’s true that we all, from time to time, experience pain that is short-lived and treatable. But those who deal with chronic pain know the debilitating, life-sucking reality of this condition. And traditional medications often come with long lists of side effects which can be as debilitating as the pain itself.
There are different ways to use CBD isolate. A popular way is to use it topically. This entails blending CBD isolate with carrier oils. CBD isolates can also be used to make edibles. For topical application, CBD can be mixed with slightly warm coconut oil to make CBD skin care products that are generously applied to the skin for conditions like acne or arthritis. For CBD edibles, the isolate can be mixed with olive oils.  CBD isolate can also be used through dabbing. This entails using special equipment known as a dab rig. This equipment looks like a bong with a bowl part that looks different. A special torch is used to heat the dab rig to a high temperature. The isolate is then put into the rig from where it is inhaled.
Many people say that you should scrub your body with leftover coffee grounds because the caffeine helps get rid of cellulite. (It is actually well documented in medical literature.) But if you feel weird about dipping into the coffee machine at the office, try this CBD-infused coffee scrub, made with coconut oil and shea butter for extra moisturizing benefits, instead. I like using it when I need a little bit of medication with my exfoliation (which the coffee grounds are for)—plus, the strong scent of coffee will wake you up if you use it in the morning. If you live with anyone else, just make sure to clean the shower afterwards—coffee scrubs can be messy and staining.
Some people don’t mind, or even enjoy the natural taste of hemp oil tinctures. For those who are bothered by the distinctive herbal taste of hemp extract, a flavored CBD oil tincture may be better. We’ve selected a variety of both flavored and unflavored CBD oil tinctures in this roundup, and many of the brands selected offer multiple options. If you still can’t stand the flavor of CBD tincture, consider another option like CBD gummies or capsules. Topical CBD is another popular choice, especially if you’re treating body aches or certain skin problems.
I think being safe to eat is a moot point. These are topical products. I don’t think anybody is buying to eat them. It’s just a marketing tactic. In regards to the chapsticks, unless you were trying to literally eat the chapstick I think whatever negligible amount may make it past your lips and into your mouth, would certainly not be a health concern from any of these products. What concerns me more is there is zero efficacy with all of these products. Do they just decide over breakfast how much CBD needs to be added for the dosage to work? It’s ridiculous that they are marketing it as safe to eat, and people are buying into that bs and providing no clinical studies or research at all. Just my 2 cents

Preliminary research indicates that cannabidiol may reduce adverse effects of THC, particularly those causing intoxication and sedation, but only at high doses.[26] Safety studies of cannabidiol showed it is well-tolerated, but may cause tiredness, diarrhea, or changes in appetite as common adverse effects.[27] Epidiolex documentation lists sleepiness, insomnia and poor quality sleep, decreased appetite, diarrhea, and fatigue.[3]
As CBD oil is non-psychoactive, applying it to the skin does not create mind-altering effects in the same manner that THC ingestion does.3 Therefore, the use of CBD in topical form is a useful alternative for those who wish to avoid the psychoactive effects of THC and those who would like options besides the over-the-counter steroid-based creams typically used for arthritis, joint pain, and similar ailments. This is especially true for aging users, parents, or adults who are concerned about practical matters (like failing drug tests, for example).

NuLeaf Naturals CBD oil tinctures are all full spectrum; it is 100% organic and never made with herbicides, pesticides, or chemical fertilizers. The brand offers a full spectrum pet CBD oil tincture, as well. NuLeaf Naturals offers free shipping to all 50 states; the brand’s products are also sold in more than 200 retail locations across the country.
To make matters more confusing, nine states (including California, Washington, and Colorado) let residents buy cannabis-based products with or without THC. Nearly two dozen other “medical marijuana states” allow the sale of cannabis, including capsules, tinctures, and other items containing CBD or THC, at licensed dispensaries to people whose doctors have certified that they have an approved condition (the list varies by state but includes chronic pain, PTSD, cancer, autism, Crohn’s disease, and multiple sclerosis). Sixteen more states legalized CBD for certain diseases. But because all these products are illegal according to the federal government, cannabis advocates are cautious. “By and large, the federal government is looking the other way,” says Paul Armentano, deputy director of the Washington, DC–based National Organization for the Reform of Marijuana Laws (NORML), but until federal laws are changed, “this administration or a future one could crack down on people who produce, manufacture, or use CBD, and the law would be on its side.”
I am in a pain management program and I was told that they test for cannabiniols across the board so even though there is no THC I could still test positive and be kicked out of the program. This is so unfair because CBC has been the best thing for PTSD anxiety and depression instead they would rather me be on multiple drugs with multiple bad side effects. Even though it’s legal in KY we re still in the dack ages. Any thoughts or help on this I would greatly appreciate how to get around it.
A 2016 review of animal studies indicated that cannabidiol has potential as an anxiolytic for relief of anxiety-related disorders and fear.[11] Reviews of preliminary research showed cannabidiol has potential for improving addictive disorders and drug dependence, although as of 2016, they indicated limited high-quality evidence for anti-addictive effects in people.[89][23][90]

THC and CBD work together.  CBD organically blocks the potency of THC, which makes the high experienced by the consumer manageable and pleasant.  THC works with CBD to amplify its medicinal qualities.  Additionally, THC has medicinal qualities of its own that are completely forgone by CBD isolate. Cannabis has more to offer than just cannabinoids; terpenes, the chemical compounds that create the plant’s scent, are also present in cannabis.

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Under federal law, cannabis (from which both CBD and marijuana are derived) is illegal everywhere, although the laws against it aren’t generally enforced in states that have legalized marijuana. Some manufacturers claim that CBD culled from legally imported industrial hemp, which has little to no THC, is fine to ship across the U.S., but many experts disagree, noting that because hemp comes from the same species as marijuana, cannabis sativa, all CBD falls under the DEA’s Schedule 1 designation. “This creative interpretation of the law runs afoul of reality,” says the Brookings Institution, a Washington, DC, think tank.
Cannabidiol (CBD), a non-psychoactive segment of the marijuana plant, has created huge enthusiasm among researchers and physicians.  CBD Oil applies its remedial effect on an atomic level is as yet being sorted out. Cannabidiol is a pleiotropic sedate in that it produces numerous impacts through various atomic pathways. CBD Oil acts through different receptor-free channels and by official with various non-cannabinoid receptors and particle channels.

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