This attention to detail extends to our carefully curated selection of CBD topical products. It’s incredibly important to us that you feel confident in your next CBD purchase, and if you’re ever unsure about anything related to CBD, our friendly and knowledgeable support team are only a click away. Browse our range of CBD salves, ointments, and other topicals, or get in touch if you have any questions.
Jump up ^ Nadulski T, Pragst F, Weinberg G, Roser P, Schnelle M, Fronk EM, Stadelmann AM (December 2005). "Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of Delta9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extract". Ther Drug Monit. 27 (6): 799–810. PMID 16306858.
Rich in CBD, cannabis has been used for centuries to fight illness, improve sleep, and lower anxiety. Today, our understanding of the potential benefits of CBD is growing by leaps and bounds—more and more, CBD is seen as a powerful disease-fighting agent. Thanks to decades of scientific investigation, it’s now possible to get the benefits of CBD in supplement form.
THC is one of the cannabinoids involved in the "entourage effect" stated earlier so it is ideal for inclusion in CBD supplementation. A recent article on full-spectrum CBD demonstrates the importance of THC inclusion by stating, "In hemp THC is a minor constituent and appears only in trace amounts under 0.3% by dry weight, as required by the U.S. government for hemp products. THC mimics the action of anandamide, a neurotransmitter naturally produced in the human body, and binds to CB1 receptors in the endocannabinoid system found mostly in the brain. The extremely low levels of THC in hemp make hemp oil non-psychoactive and safe for all ages to use."
Cannabis topicals are often made in the form of lotion, oil, salves, and balms. Any sort of topical cream or oil you can think of has already been given the cannabinoid treatment with CBD Topical Cream. Products of this kind are made with active cannabinoids that are absorbed into your system directly through your skin. Topicals can owe their popularity in recent times largely to the wide variety of products available. CBD has even made its way into lip balms, body butters, general cosmetics for the skin, and a number of hair care products.

Thanks for your interest in our products. Unfortunately due to strict FDA regulations I am unable to make claims on our products based on your specific needs, I can however share our top selling products in each category. Please view the links below:http://cbdoilreview.org/product/elixinol-cbd-oil-extract-x-pen-1000mg/http://cbdoilreview.org/product/endoca-hemp-oil-drops-1500mg/http://cbdoilreview.org/product/elixinol-hemp-oil-drops-regular-300mg/http://cbdoilreview.org/product/elixinol-cbd-hemp-oil-capsules-900mg/https://cbdoilreview.org/product/vape-bright-starter-pack-200-mg/This is also a great link to some pages that you may find helpful https://cbdoilreview.org/cbd-cannabidiol/I hope this helps and if you have any further questions please feel free to reach out to us at [email protected]
Our CBD Hemp Oils are extracted from our own proprietary strain of hemp grown specifically for pets, PR-33.  This strain is grown at the largest certified USDA organic hemp farm in the United States. Our joint-partnership with our farmers allows us to have complete control over our hemp plants, from seed to sale, from plant to pet we know exactly what’s going into the products you’re giving your pets.

Ian Jones is a journalist based in Manchester, England. He specialises in technology and food, with a heavy focus on vaping, CBD and medicinal drugs. He began writing professionally over 15 years ago and is a regular contributor to New Scientist, Vice and the Daily Mirror. He is also the resident CBD expert at the respected vaping website Spinfuel. He began looking at CBD in detail after discovering that it cured his mother's arthritis, and has since become a leading figure in the UK when it comes to educating people about the CBD extraction process and exploring its curative properties.
Thousands of people have learned about the healing benefits of CBD, resulting in unprecedented interest in this supplement. People are using CBD oil to ease their chronic pain, and relieve symptoms of conditions ranging from arthritis to depression. Unlike its close cousin, psychoactive cannabis (‘marijuana’), CBD oil won’t make you feel high — but many users report significant relief of their symptoms. Even the World Health Organization declared CBD oil safe and worthy of deeper research.
For some, having more than trace amounts of Tetrahydrocannabinol (THC) might not be a big deal, but if you’re being drug tested at work, operating heavy machinery, or fall into a number of other categories, you may want to keep the THC to a bare minimum. In order to qualify as a legal hemp product, CBD oil must contain less than 0.03% THC. Look for CBD oil certified to have low levels of, or zero, THC in them. Many reputable sellers do offer products that have absolutely no THC in them at all, so if you are concerned about keeping even trace amounts of TCH out of your body, it is best to look for those products and sellers.
The chemical compounds responsible for the way marijuana effects users are known as cannabinoids.  The cannabis plant contains about 85 cannabinoids, with the two most widely discussed being CBD and THC. While THC is what is responsible for cannabis’ psychoactive properties, Cannabidiol (CBD), is non-psychoactive and comes with a lot of healing properties. CBD isolate is what it sounds like: the extraction of CBD from the cannabis plant so that the subsequent product is “pure” CBD.  Companies that do this use some kind of extraction process, likely CO2.  They remove unwanted plant material from the extraction, giving you a concentrated CBD isolate, which only amplifies the healing properties of the cannabinoid.

As a representative with 2 companies that have CBD on the market and as a person with intractable pain and multple painful problems wirth my spine I can say that cbd does not work for everyone. It does nothing for me or for my mil who has a cancer like growth impeding her ability to swallow and has undergone radiation to shrink it. Everyone has a chemistry that’s personal to them for some it helps but for many it does not. With that in mind it’s a 50/50 chance of it helping and until you come out your pocket you’ll never know. Buyer beware.
The positive health benefits of CBD oil for pets are scientifically proven and we quickly learned that by taking advantage of the full spectrum of cannabinoids offered by the hemp plant, and not just CBD, Pet Releaf products are effectively activating your pet’s Endocannabinoid System (ECS). What happens when the ECS is turned on? It’s the only time 2-way communication (homeostasis) is happening within the body. Without full spectrum CBD, your pet’s brain is only able to guess where their body needs more support. When taking Pet Releaf CBD for pets, the body is able to tell the brain exactly where it’s needing more help and assistance. Because of this, Pet Releaf products are a potent anti-inflammatory and turbo boost to the immune system.
Cannabidiol has been found to act as an antagonist of GPR55, a G protein-coupled receptor and putative cannabinoid receptor that is expressed in the caudate nucleus and putamen in the brain.[35] It has also been found to act as an inverse agonist of GPR3, GPR6, and GPR12.[12] Although currently classified as orphan receptors, these receptors are most closely related phylogenetically to the cannabinoid receptors.[12] In addition to orphan receptors, CBD has been shown to act as a serotonin 5-HT1A receptor partial agonist,[36] and this action may be involved in its antidepressant,[37][38] anxiolytic,[38][39] and neuroprotective effects.[40][41] It is an allosteric modulator of the μ- and δ-opioid receptors as well.[42] The pharmacological effects of CBD have additionally been attributed to PPARγ agonism and intracellular calcium release.[8]
We are staunch advocates of CBD and its many, amazing, scientifically-backed uses. We are also staunch advocates of our patrons and their access to the highest quality, 100% organic CBD products around. Getting the information you need, the exact product you want, and a no hassle transaction with no attached shipping charges – that’s what we are all about.
The second method of pain relief centers around the damage you do when you work out. When you strength train, you create micro-tears in your muscles, which is why you feel sore as you heal. Once your immune cells detect damage, they release inflammatory mediators in order to repair the tissue. CBD, though has the ability to limit the release of some proinflammatory signals, thereby helping with pain without thwarting the healing entirely, Gerdeman explains.
Hi Chris, the whole “product labeling” thing from brand to brand is definitely super confusing. Because the industry is so unregulated, companies can label their products “hemp oil,” “CBD oil,” “hemp extract oil,” etc, and there’s really no way to distinguish between them or tell what’s actually in them — unless they have a lab report. Basically, if you don’t see the word “CBD” anywhere on the label or on the product description, the oil is probably made from hemp seeds (in which case it has no CBD). The only sure way to know you’re getting an oil with CBD in it is to find something with a certified lab report showing the exact amount of CBD (and even still, some companies have been known to fudge their way around this). I know this isn’t the most clear-cut answer, but again, given how unregulated the industry is, there’s really no “perfect” answer. Hope this helps a little bit 🙂
Finally, in general, we almost always recommend full spectrum tinctures over supplements made from isolates (extracts of CBD alone). Full-spectrum or whole plant tinctures take advantage of the ‘entourage effect’ that comes from combining all the naturally occurring chemicals found in the hemp plant. Isolates are great for cooking with CBD or consumers that are especially sensitive to the taste of hemp extract, but some research suggests they may be less effective for certain uses than full spectrum extracts. All but two of the brands below are made from full spectrum hemp, and the exceptions are clearly noted.
The key difference between hemp and marijuana is that hemp contains practically zero THC. In fact, in order to be classified as hemp, a cannabis plant must contain less than 0.3% THC by volume. This is really important because it’s actually the reason why hemp products are legal to buy, sell, and ship. If they don’t get you high, then why would they be illegal?
They may be safe, but there's one massive problem: There's practically no scientific data to support the idea that a CBD-infused topical cream is any more effective than other topical pain relievers, like Tiger Balm, BenGay, or Icy Hot. Michelle Sexton, a San Diego-based naturopathic doctor and medical research director of the Center for the Study of Cannabis and Social Policy says that her patients do seem to have a great interest in CBD ointments, and roughly 40 percent of them have indeed tried one. However, these people are in her office now because the topicals didn’t work for them. "As a medical professional, my opinion is there’s little evidence to back up the claims being made—it’s all marketing for now," she says.
Winterization is just a fancy science term for cooling down a chemical substance in order to remove impurities. So, in the case of CBD isolate, winterization removes excess waxes, but it also removes the terpenes, trichomes, and flavonoids. There’s a big debate raging around whole-plant cannabis vs. isolates because the chemicals that are removed to produce an isolate can have beneficial effects when taken together.
Strength is also an extremely important consideration. Beginners may find that it’s easier to control dosage using a lower strength tincture. On the other hand, experienced CBD consumers know that high strength tinctures are more cost effective. Although stronger tinctures cost more, you get more CBD oil and other beneficial cannabinoids in each drop. Most CBD brands offer more than one option for strength.
Bored with your run-of-the-mill vape liquids? Want to try the alternative everyone’s talking about? This Silver Blend CBD e-Liquid from Alternate Vape is a game-changer. Individually crafted, incredibly flavorful, and packed with CBD, you’ll never vape the same again. Choose from one of six imaginative and tantalizing flavors to elevate your vaping experience to a whole new level.

I was sceptical, but decided to try the cream for my chronic hip pain! It was amazing! Within 15 minutes, my pain is almost gone! I am a nurse and am on my feet ALOT! I am so excited about this product that I share my experience with my patients and friends that have pain issues! It feels so good to be using a natural product that has no side effects and that actually works!! Thank you so much!

I just started taking CBD oil , I am on my 2nd Hip replacement surgery due to device failures looking at a 3rd surgery. Has you can imagine the pain, stress and anxiety levels are off the charts. Especially at an otherwise healthy 54 yr women. So i understand from reading posts its best to take it under the tongue. I am taking 1-2 ml a day. I can tell some difference,is your recommended dosage. I am using for pain , stress and sleep. I appreciate your feedback.
My husband was diagnosed with ALS (amyotrophic lateral sclerosis) when he was 61 years old 4 years ago. The Rilutek (riluzole) did very little to help him. The medical team did even less. His decline was rapid and devastating. His arms weakened first, then his hands and legs. Last year, a family friend told us about Rich Herbs Foundation (RHF) and their successful ALS TREATMENT, we visited their website www. richherbsfoundation. com and ordered their ALS/MND Formula, i am happy to report the treatment effectively treated and reversed his Amyotrophic Lateral Sclerosis (ALS), most of the symptoms stopped, he is able to walk and able to ride his treadmill again, he is pretty active now.
Our BioCBD Plus™ products are made of water soluble CBD. In fact we are the original providers of water soluble CBD in the market place. This means that our products are multiple times more effective than CBD Oil due to its higher absorption rate. Add on top of that our nanotechnology and we provide the highest absorption rate in the industry, upwards of 90+%.
My bigger question is what about analytics ? So many bad lab’s out there in Cannabis and Hemp. Did they test for Pesticides ? Mycotoxins ? Heavy Metals (Hemp is great at dragging up heavy metals from the soil as well as from nutrient solutions, herbicides, etc..). The testing piece is critical and that a lab performs random testing to ensure that the final products on the shelf actually contain what’s on the label. Even good test results mean nothing if the product is cut after the testing.
Plus CBD Oil™ products come in a variety of flavors and concentrations to suit your preferences. If you are considering CBD oil for your health, as with any supplement, we encourage you to speak with your physician and dive into the research to learn more about this promising phytonutrient. We at Plus CBD Oil™ are proud of our innovative selection of products.
Correct Answer: Each batch of flower AND finished product should be tested by a state certified testing facility for potency, legality and safety. These test results should also be made available to any patient that requests them. These tests should certify 3 things: the amount of CBD contained in the product, the amount of THC in the product (the starting hemp plant material must test below 0.3%), and the lack of mold or toxic pesticides.
The hemp used to make this CBD oil is extracted from a special variety of sustainably raised, organic hemp that is specifically bred to contain naturally high concentrations of CBD, while still containing all of the natural cannabinoids, terpenoids, and other compounds of the original plant. The resulting oil then is strictly tested for purity and is free from pesticides and heavy metals.
There are new CBD companies coming online every week – these span the range from truly awful to really great. So how to choose the best? The quality of the CBD oil itself is obviously the most important factor – and many companies do take the quality of their products seriously. To reward those companies, we gave more weight to the quality of the product than any other category.
All of our industrial hemp is grown and extracted in accordance with the strict guidelines of the Kentucky Department of Agriculture. Utilizing a whole plant CO2 extraction allows us to draw the CBD from the plant material and filter out unnatural substances, maximizing pure CBD concentration. Derived from US grown hemp, our isolate is one of the purest isolates available with 0% THC, guaranteed.
Some companies will hide under a cloak of darkness that the Internet can provide, but it’s a pretty good sign if the company lists an honest-to-goodness phone number you can use to reach real people. The companies with inferior products will often be very difficult to reach. Before ordering, try to reach out to the company. If someone picks up the phone or gets back to you in a timely manner, you’ve probably found a company that not only takes accountability seriously, but cares about their customers and the quality of their products.

The increased popularity of CBD has led many users to raise questions about the methods of extracting and administering CBD. The main question is which form provides the most effective range of medical benefits for the user. The two most common forms of extracted CBD found in stores are full-spectrum (whole-plant extract) and pure CBD isolate. Most users prefer the full-spectrum option. As CBD's usefulness for medical purposes has become more accepted over the years, new methods of administering it have continued to evolve.
...with due respect, your experience Locsta is almost precisely what happened with my....chihuahua. Degenerative disc disease, excruciating pain, prednisone worked, but couldn't keep her on it..pain killers and muscle relaxants didn't help, really thought I would have to put her down. Chi bloggers suggested CBD; gave PetReleaf a shot--like you, literally within minutes I could see the difference, in days she was pain free and now is back in charge of our world. The real key here is that with my dog, there is zero, nada, chance that there was any placebo effect...
Every BioCBD Plus™ product is more than just water soluble CBD. All of our products feature a proprietary Ayurvedic blend of water soluble cannabinoids, terpenes and different Ayurvedic herbs. We understand the desire to know the exact amounts of ingredients in each of our Ayurvedic blends, and we wish we could share that information with you without jeopardizing our trade secrets. What we can share with you is this Ayurvedic blend is Hemp Oil (CBD), Curcumin, Eucalyptus, Ginger, White Willow Bark & Burseraceae).
All this means that scientists can still only obtain marijuana-derived CBD from farms licensed by the National Institute on Drug Abuse (which until this year meant only one farm owned by the University of Mississippi). As for whether you should have a preference for CBD that comes from hemp, marijuana, or a pure synthetically produced version, there are some theories that THC—and even the smell and taste of cannabis—might make CBD more effective, but Bonn-Miller says these ideas have yet to be proven.

Lisa Hamilton, a jeweler and doula in Brooklyn, NY, knows about the side effects. She recently tried CBD for the shoulder pain that plagued her five years after an accident. Her doctor certified that she was in chronic pain, which under New York State law allowed her to buy from a state dispensary. One Friday, she swallowed two 10-mg capsules, the amount recommended at the dispensary, then took another two on Saturday. “By Sunday, it felt like I’d gotten hit by a truck. Every muscle and joint ached,” Hamilton says. She cut back to one pill a day the following week, but still felt hungover. She stopped after that.


I LOVE my CBD pain cream. It is called “CAD” (short for Carter’s Aromatherapy Designs) cream. The downside is that it’s uber expensive ($45 to $140, for a 2 ounce jar, depending on the strength), but the little jar does seem to stretch quite a way. It smells of peppermint, not skunk. I’m currently experimenting with making my own from home-grown AC/DC. So far, I like the CAD better.
At Charlotte's Web, we stand behind our products 100%. We work hard to ensure that our quality is second to none, and thousands of our customers agree that this difference is something you will experience. We’re so convinced our products will make a difference you can actually feel, that if any product doesn’t meet your expectations, we want you to send it back within the first 30 days of delivery and we will happily give you the opportunity to exchange for another product or receive a full refund.

In addition to acting on the brain, CBD influences many body processes. That’s due to the endocannabinoid system (ECS), which was discovered in the 1990s, after scientists started investigating why pot produces a high. Although much less well-known than the cardiovascular, reproductive, and respiratory systems, the ECS is critical. “The ECS helps us eat, sleep, relax, forget what we don’t need to remember, and protect our bodies from harm,” Marcu says. There are more ECS receptors in the brain than there are for opioids or serotonin, plus others in the intestines, liver, pancreas, ovaries, bone cells, and elsewhere.
Food and beverage products containing CBD were introduced in the United States in 2017.[54] Similar to energy drinks and protein bars which may contain vitamin or herbal additives, food and beverage items can be infused with CBD as an alternative means of ingesting the substance.[55] In the United States, numerous products are marketed as containing CBD, but in reality contain little or none.[56] Some companies marketing CBD-infused food products with claims that are similar to the effects of prescription drugs have received warning letters from the Food and Drug Administration for making unsubstantiated health claims.[57]
Correct Answer: Each batch of flower AND finished product should be tested by a state certified testing facility for potency, legality and safety. These test results should also be made available to any patient that requests them. These tests should certify 3 things: the amount of CBD contained in the product, the amount of THC in the product (the starting hemp plant material must test below 0.3%), and the lack of mold or toxic pesticides.
Removing all other molecules from the cannabis plant potentially removes—or at least seriously alters—the therapeutic effects that naturally occur when those compounds are working synergistically.  In fact, studies show that when used in combination with THC, it takes less CBD to produce the desired medicinal outcome than when CBD isolate is used instead.
At the end of the extraction process, you’re left with a cannabis concentrate. Depending on the form in which you choose to keep the cannabis concentrate (e.g., solid, semi-solid, liquid), you can then make things like shatter, wax, oil, and tincture. But if you want to make CBD isolate, you’ll need to refine that concentrate a little bit more with a process called winterization.
Until 2017, products containing cannabidiol that are marketed for medical purposes were classed as medicines by the UK regulatory body, the Medicines and Healthcare products Regulatory Agency (MHRA) and could not be marketed without regulatory approval for the medical claims.[85] CBD oil with THC content not exceeding 0.2% was legalized throughout the UK in 2017.[citation needed] Cannabis oil, however, remained illegal to possess, buy and sell.[86]
With the rapid growth of the CBD industry and constant advances in its technology, there are a lot of terms floating around that are unfamiliar, if not confusing, to many people. “Nano-Amplified CBD” is one of them. While the science and biological make-up of CBD is the subject of much research and scholarly articles, it can all be broken down into simple terms.
Cannabidiol, or CBD for short, is a phyto-cannabinoid found in cannabis plants. However, it does not cause the same psychoactive effects as other naturally occurring cannabinoids (such as tetrahydrocannabinol, or THC). CBD induces feelings of sleepiness and tranquility, making it suitable for insomnia and other sleep disorders; CBD can be used to alleviate symptoms of epilepsy, diabetes, and anxiety disorders, as well. Legality is an issue for some; all 50 states have laws governing the sale, possession, and use of CBD, and they vary significantly (see the table below for a full analysis).
At Charlotte's Web, we stand behind our products 100%. We work hard to ensure that our quality is second to none, and thousands of our customers agree that this difference is something you will experience. We’re so convinced our products will make a difference you can actually feel, that if any product doesn’t meet your expectations, we want you to send it back within the first 30 days of delivery and we will happily give you the opportunity to exchange for another product or receive a full refund.

Most users find that regular application provides an analgesic effect that significantly reduces localized discomfort.2 Even though CBD is most often taken for pain relief, research is showing it to be beneficial in relieving, cramps, headaches, and psoriasis. CBD’s effects can increase the natural levels of pain-relieving endocannabinoids, decrease inflammatory responses, and desensitize pain receptors.2
CBD IS AN ABBREVIATION FOR CANNABIDIOL, A CHEMICAL COMPOUND FOUND NATURALLY IN THE HEMP PLANT. IT IS NOT MIND ALTERING LIKE MARIJUANA, WHICH MEANS CBD OIL WILL NOT MAKE YOU HIGH. OVER THE PAST 40 YEARS THERE HAVE BEEN NUMEROUS STUDIES THAT HIGHLIGHT THE POTENTIAL OF CBD. RESEARCHERS DISCOVERED THE HUMAN ENDOCANNABINOID SYSTEM (ECS), WHICH IS THE SYSTEM THAT CBD INTERACTS WITH.
The CBD vaporizer category is pretty crowded, but this CBD Vape Shot Kit from Alternate Vape continues to win the hearts of our customers, even over more expensive versions. The device itself is small, portable, lightweight, convenient, and easy to use. Simply add your favorite flavor, screw on the top, and you’re ready to start vaping. It’s the ideal starter kit for beginners new to CBD vaping, and it comes with everything you need: one e-pen, one USB charger, and one pre-loaded CBD cartridge.
Food and beverage products containing CBD were introduced in the United States in 2017.[54] Similar to energy drinks and protein bars which may contain vitamin or herbal additives, food and beverage items can be infused with CBD as an alternative means of ingesting the substance.[55] In the United States, numerous products are marketed as containing CBD, but in reality contain little or none.[56] Some companies marketing CBD-infused food products with claims that are similar to the effects of prescription drugs have received warning letters from the Food and Drug Administration for making unsubstantiated health claims.[57]
I have been suffering from scalp pain, itching and scalp sores for more than 3 years. I have seen 6 dermatologists and 5 diagnosed me with folliculitis. The 6th dermatologist felt I did not have folliculitis, but dysesthesia. I am interested in trying a cannabis scalp cream, but know nothing about this product, and where I might get it, and if it might work for me. I have had 7/7 pain for 3.5 years and need some relief other than narcotics.
Lisa Hamilton, a jeweler and doula in Brooklyn, NY, knows about the side effects. She recently tried CBD for the shoulder pain that plagued her five years after an accident. Her doctor certified that she was in chronic pain, which under New York State law allowed her to buy from a state dispensary. One Friday, she swallowed two 10-mg capsules, the amount recommended at the dispensary, then took another two on Saturday. “By Sunday, it felt like I’d gotten hit by a truck. Every muscle and joint ached,” Hamilton says. She cut back to one pill a day the following week, but still felt hungover. She stopped after that.
They may be safe, but there's one massive problem: There's practically no scientific data to support the idea that a CBD-infused topical cream is any more effective than other topical pain relievers, like Tiger Balm, BenGay, or Icy Hot. Michelle Sexton, a San Diego-based naturopathic doctor and medical research director of the Center for the Study of Cannabis and Social Policy says that her patients do seem to have a great interest in CBD ointments, and roughly 40 percent of them have indeed tried one. However, these people are in her office now because the topicals didn’t work for them. "As a medical professional, my opinion is there’s little evidence to back up the claims being made—it’s all marketing for now," she says.
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