Scientists have made a lot of progress in understanding how CBD produces its calming, pain-reducing, anti-inflammatory effects in the body—and there’s still more to learn. We know that CBD interacts with many different receptors, proteins, and other chemicals in the brain. These interactions create changes in the activity of neurotransmitters, hormones, and other cells throughout the brain and body. Through these interactions, CBD appears to be able to affect many of the body’s functions, from sleep-wake cycles and emotional regulation to inflammation, pain perception, and seizures.
I can’t assist with what you need, but I can tell you that I am a cancer survivor ( 15 years), with Chronic Fibro, arthritis and nerve damage . I was on prescribed pain meds for a long time. CBD has been a life saver. I have tried several of the above. For me, Bluebird is the best so far of them all. In terms of effectiveness , its heads and tails ( no pun intended) above the rest. They do have a program as well , yes. They are pricey . I also like Lazarus’s 25 mg Capsules as well.
I have severe neuropathy in both feet and legs. I just got the CBD oil and I am interested in learning if anyone out there has had any success with this. I know each case and pain levels are different. Just would like to see some positive remarks from people who suffer with it. I am not looking for a cure just need an update on someone who took and it helped. I already know there is no cure. I need help with the pain. Thank you.
...with due respect, your experience Locsta is almost precisely what happened with my....chihuahua. Degenerative disc disease, excruciating pain, prednisone worked, but couldn't keep her on it..pain killers and muscle relaxants didn't help, really thought I would have to put her down. Chi bloggers suggested CBD; gave PetReleaf a shot--like you, literally within minutes I could see the difference, in days she was pain free and now is back in charge of our world. The real key here is that with my dog, there is zero, nada, chance that there was any placebo effect...
I am in a pain management program and I was told that they test for cannabiniols across the board so even though there is no THC I could still test positive and be kicked out of the program. This is so unfair because CBC has been the best thing for PTSD anxiety and depression instead they would rather me be on multiple drugs with multiple bad side effects. Even though it’s legal in KY we re still in the dack ages. Any thoughts or help on this I would greatly appreciate how to get around it.
CBD oil is similar to other products in that it is capable of being “watered down.” Some companies will try to eke out a higher profit margin by fooling their customers into thinking they’re getting more for less. It is important to pay attention to the concentration level of the CBD oil you’re buying in order to ensure you’re getting what you’re paying for. Although concentrations of CBD can vary quite a bit across the broad range of CBD products, a quality product will start off having somewhere between 250mg to 1,000mg per fluid ounce. This matters because if you were to purchase a 4 ounce bottle that contained 250mg of CBD, your concentration would be a mere 62.5 mg of CBD per ounce – hardly enough to reap the full benefits of CBD. It’s always important to look at the concentration level of the CBD you’re buying.
It's the Wild West out there. Without any federal regulatory body checking labels, consumers have very little way of knowing what they're buying when they purchase CBD oil. Bonn-Miller co-authored a study that found that 26 percent of CBD products on the market contained less CBD than their label claimed. So the amount you need for an effective dose could vary drastically, not just from product to product, but from bottle to bottle of the same product.

I think being safe to eat is a moot point. These are topical products. I don’t think anybody is buying to eat them. It’s just a marketing tactic. In regards to the chapsticks, unless you were trying to literally eat the chapstick I think whatever negligible amount may make it past your lips and into your mouth, would certainly not be a health concern from any of these products. What concerns me more is there is zero efficacy with all of these products. Do they just decide over breakfast how much CBD needs to be added for the dosage to work? It’s ridiculous that they are marketing it as safe to eat, and people are buying into that bs and providing no clinical studies or research at all. Just my 2 cents

CBD IS AN ABBREVIATION FOR CANNABIDIOL, A CHEMICAL COMPOUND FOUND NATURALLY IN THE HEMP PLANT. IT IS NOT MIND ALTERING LIKE MARIJUANA, WHICH MEANS CBD OIL WILL NOT MAKE YOU HIGH. OVER THE PAST 40 YEARS THERE HAVE BEEN NUMEROUS STUDIES THAT HIGHLIGHT THE POTENTIAL OF CBD. RESEARCHERS DISCOVERED THE HUMAN ENDOCANNABINOID SYSTEM (ECS), WHICH IS THE SYSTEM THAT CBD INTERACTS WITH.
Vaping, tinctures, topicals—they all have their qualities, but does anything beat the decadence and sheer enjoyment of dark chocolate? These Tasty Cocoas CBD Chocolates from Tasty Hemp Oil come individually wrapped, ready to deliver a delicious serving of soothing CBD. Made with the highest-quality cocoa and raw hemp oil, these chocolates are available in dark and dark mint variations.
Back pain can be extremely debilitating, and it’s understandable if you want to steer clear of pharmaceutical painkillers in favor of something a little more natural. That’s what makes this Green Label Raw CBD Oil from Herbal Renewals so special. Available in three sizes, it’s a potent concentrate that gets to work in around fifteen minutes, and it can last for up to twelve hours, bringing real relief to back aches.
Medterra's dissolvable sleep tablets combine 25mg of CBD with 10mg of melatonin to provide a restful nights sleep. Simply place the tablet under your tongue before bedtime and allow it to dissolve before swallowing. Each tablet is scored to allow for the user to consume half (1/2) of a tablet if they are sensitive to melatonin. Tablets contain natural spearmint flavoring.

Pharmacists have since moved to metric measurements, with a drop being rounded to exactly 0.05 mL (50 μL, that is, 20 drops per milliliter) - https://en.wikipedia.org/wiki/Drop_(unit)1oz is 30 mL1000mg/30mL = 33.3 mg/mL CBD concentration20 drops * .05 mL/drop = 1mL10 drops * .05 mL/drop = .5mLyou take 33.3 mg in the morning and 16.65mg at nightI might suggest taking 50mg in the morning: 50mg / 33.3 mg/mL = 1.50 mL 30 dropstry it for a couple days and see how it helps
At the end of the extraction process, you’re left with a cannabis concentrate. Depending on the form in which you choose to keep the cannabis concentrate (e.g., solid, semi-solid, liquid), you can then make things like shatter, wax, oil, and tincture. But if you want to make CBD isolate, you’ll need to refine that concentrate a little bit more with a process called winterization.

Hi, Congrats on finishing chemo & radiation that’s awesome!! I wish you the best of luck!! I was actually wanting to know about dosage for cancer as well..My parents both have recently been diagnosed with cancer 4 months apart and are currently going thru chemo together. I have tried looking for the dosage info but can never find what i’m looking for..I want to try to help lesson the chemo side effects and hopefully kill some of the cancer cells. Can someone please help us?Thank You Christy
Tammy et al, Through trial and error you will find a correct dosage. Try 50 mg daily....25 each 2x daily....if no results up the dosage until it works for you. Remember, there has never been a death from marijuana or CBD use. You might want to try a tincture or rub with CBD and THC. You won't get the psych high from it. Helps my friend with PArkinsons tremors. She takes 50mg of tincture and uses the rub morning and night. It is a miracle for arthritis. Good luck
Lisa Hamilton, a jeweler and doula in Brooklyn, NY, knows about the side effects. She recently tried CBD for the shoulder pain that plagued her five years after an accident. Her doctor certified that she was in chronic pain, which under New York State law allowed her to buy from a state dispensary. One Friday, she swallowed two 10-mg capsules, the amount recommended at the dispensary, then took another two on Saturday. “By Sunday, it felt like I’d gotten hit by a truck. Every muscle and joint ached,” Hamilton says. She cut back to one pill a day the following week, but still felt hungover. She stopped after that.

Inhibited liver function: The liver regulates the way different drugs are metabolized within the body; this process is known as hepatic drug metabolism. Higher-than-average doses of CBD oil can slow the hepatic drug metabolism process. As a result, users may not be able to process other drugs as quickly. This is particularly concerning for CBD oil users who also take prescription medications.

Jump up ^ Klein C, Karanges E, Spiro A, Wong A, Spencer J, Huynh T, Gunasekaran N, Karl T, Long LE, Huang XF, Liu K, Arnold JC, McGregor IS (November 2011). "Cannabidiol potentiates Δ⁹-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats". Psychopharmacology. 218 (2): 443–457. doi:10.1007/s00213-011-2342-0. PMID 21667074.

Although it’s a relatively new product in the Cannabidiol hemp oil industry, CBD isolate extraction and CBD isolate ingestion is taking the cannabinoid market by storm, becoming increasingly popular with retail customers, formulators, and wholesalers alike. Its many uses and applications in this unmodified form are almost endless and its versatility unparalleled. Plus, you are put in complete control of exactly how much Cannabidiol goes into each serving.
A CNN program that featured Charlotte's Web cannabis in 2013 brought increased attention to the use of CBD in the treatment of seizure disorders.[68][69] Since then, 16 states have passed laws to allow the use of CBD products with a doctor's recommendation (instead of a prescription) for treatment of certain medical conditions.[70] This is in addition to the 30 states that have passed comprehensive medical cannabis laws, which allow for the use of cannabis products with no restrictions on THC content.[70] Of these 30 states, eight have legalized the use and sale of cannabis products without requirement for a doctor's recommendation.[70]
A CNN program that featured Charlotte's Web cannabis in 2013 brought increased attention to the use of CBD in the treatment of seizure disorders.[68][69] Since then, 16 states have passed laws to allow the use of CBD products with a doctor's recommendation (instead of a prescription) for treatment of certain medical conditions.[70] This is in addition to the 30 states that have passed comprehensive medical cannabis laws, which allow for the use of cannabis products with no restrictions on THC content.[70] Of these 30 states, eight have legalized the use and sale of cannabis products without requirement for a doctor's recommendation.[70]

I suffered from severe eczema as a child and, thankfully, grew out of it for the most part. Eczema is skin with a weak barrier that makes the sufferer’s skin much more open to irritants and allergens, causing a lot of discomfort. This irritation/allergic reaction leads to itching, bacterial infections, over-moisturizing which can lead to yeast overgrowth, etc. Once the chain reaction is set off, it is very difficult to stop. As a child, my parents would come in after I went to sleep, slather my legs with aquaphor and wrap them in ace bandages. It was a sticky mess but somewhat effective. To soothe my dry and easily irritated adult skin (as well as my arthritis), I make a cannabis product wth beeswax, shea butter, coconut oil, and a handful of healing herbs. Beeswax is a great barrier/protectant and has other beneficial properties. The Shea butter is very similar to sebum in our skin so acts to supplement our natural protection.


Jump up ^ Hayakawa K, Mishima K, Hazekawa M, Sano K, Irie K, Orito K, Egawa T, Kitamura Y, Uchida N, Nishimura R, Egashira N, Iwasaki K, Fujiwara M (January 2008). "Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism". Brain Research. 1188: 157–64. doi:10.1016/j.brainres.2007.09.090. PMID 18021759.
My husband has RSD and we are considering CBD oil -= I would ask at Hempmed because the spray won't have enough in it. Our dgt';s friend has ovarian cancer and it is shrinking her tumors but the spray would never have been enough. I would get CBD oil and check with Hempmeds to see what they suggest. It isn't cheap but it does work. LOW dose Naltrexone about 4.5 mg is very helpful for RSD and is usually used for getting people off of drugs but is working on turning off the glial cells that surround the nerve that is causing the nerve to scream in pain. We are also using PeaPure that is out of the Netherlands and we are seeing a response, even though small. His other leg touched the painful leg without causing more severe pain. That is progress. We also are using Poison Ivy Cream through Meadowlake Farms that has helped the burning surface pain. Change your diet and get rid of Gluten and Sugar, anything that causes inflammation. This is to allow your own body to work. Absolutely do not use any pain killers as it will turn up your pain. all the Hydrocodone, etc causes neural inflammation and so it will keep cascading higher your pain. Hope this is helpful. Mary

That leaves those touting CBD’s effectiveness pointing primarily to research in mice and petri dishes. There, CBD (sometimes combined with small amounts of THC) has shown promise for helping pain, neurological conditions like anxiety and PTSD, and the immune system—and therefore potentially arthritis, diabetes, multiple sclerosis, cancer, and more.
The ointment is made from infusing high-quality cannabis flowers in some kind of quality oil—coconut or olive typically—which extracts the active compounds, either CBD, THC, or both depending on the type of hemp used. This oil is then blended with other therapeutic herbs, like arnica or lemongrass essential oils, that are well-known pain relievers.
As simple as the extraction and refining processes sound, they’re really not. Certain extraction methods can be done at home, but winterization is a bit more complicated than just storing your cannabis concentrate in the freezer for a few days. If you’re interested in trying CBD isolate for yourself, we highly recommend that purchasing it rather than making it yourself.
Maintain a clear mind and active lifestyle with Endoca™ CBD hemp oil! - Hemp oil extracts have traditionally been used around the globe as medicine. A large body of evidence has indicated that the benefits of CBD hemp oil can relieve various ailments. Endoca maintains the biochemical equilibrium within the hemp plants to maximize the beneficial effects of its organic CBD oil.
You can also take CBD isolate directly. Simply add it to coconut oil (we recco the MCT version) and drop it under your tongue. When placed under the tongue and held for 60-90 seconds, the CBD isolate coconut oil enters the bloodstream faster than if swallowed, avoiding first passing the metabolism. Taking your servings of CBD isolate sublingually is the easiest, most straightforward method for use.
Though unflavored and priced higher than competitors, Green Roads CBD oils are made by a trusted manufacturer and use organically grown hemp. Following the CO2 supercritical fluid extraction process, board-certified pharmacists formulate the tincture by hand. Green Roads only sells CBD isolates, so if you’re looking for broad-spectrum products look to some of our other recommendations.
Online retailers: Most CBD oils are sold through online retailers. These establishments tend to have the widest product range, and many offer free doorstep delivery. Online retailers also frequently post product reviews, allowing buyers to compare different oils based on customer experiences to determine which is best for them. These reviews can also be used to evaluate the retailer based on customer service, delivery, and product quality.
The views expressed in this article are intended to spark conversation and highlight alternative studies and is for information purposes only. We are not here to diagnose or treat any health or medical conditions, nor should this be relied upon as a substitute for professional medical advice, diagnosis or treatment, even if it features the advice of health experts, medical practitioners or physicians. When making any lifestyle or health changes, consult your primary care physician. The views expressed in this article are the views of the author and do not necessarily represent the views of Organic Authority, Inc.
Even if a topical contains active THC, it still won’t induce that intense “high” you’d get from smoking or ingesting cannabis. With most topicals, cannabinoids can’t breach the bloodstream; they only penetrate to the system of CB2 receptors. Transdermal patches, however, do deliver cannabinoids to the bloodstream and could have psychoactive effects with a high enough THC content.
If you haven’t been bombarded with CBD marketing or raves about it from friends, get ready. This extract—which comes from either marijuana or its industrial cousin, hemp—is popping up everywhere. There are CBD capsules, tinctures, and liquids for vaping plus CBD-infused lotions, beauty products, snacks, coffee, and even vaginal suppositories. Already some 1,000 brands of CBD products are available in stores—and online in states that don’t have lenient cannabis laws. This is a tiny fraction of what’s to come: The CBD market is poised to exceed $1 billion by 2020, per the Chicago-based research firm Brightfield Group.
As you become more comfortable adding CBD isolate to your favorite foods and snacks, take it step further. Use a double boiler or similar technique to add CBD isolate to honey or agave nectar. As the honey or nectar is heated, the CBD isolate will dissolve, mixing right into the viscous sweetener. Once fully dissolved, your CBD-infused honey or agave can be used to sweeten coffees and teas, topped over fruit bowls or granola, or drizzled on avocado toast for a healthy, CBD-fueled start to your day. The choices are many and varied, and they’re all yours!
Zuardi, A. W., Crippa, J. A., Hallak, J. E., Bhattacharyya, S., Atakan, Z., Martin-Santos, R., … & Guimarães, F. S. (2012). A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation [Abstract]. Current Pharmaceutical Design, 18(32), 5,131–5,140. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22716160
Winterization is just a fancy science term for cooling down a chemical substance in order to remove impurities. So, in the case of CBD isolate, winterization removes excess waxes, but it also removes the terpenes, trichomes, and flavonoids. There’s a big debate raging around whole-plant cannabis vs. isolates because the chemicals that are removed to produce an isolate can have beneficial effects when taken together.
In the early days of cannabis culture—we’re talking the 1960s, 70s, and 80s, before CBD isolate was a gleam in some stoner chemist’s eye—you pretty much only had two ways to consume your chronic: smoke it or bake it in a brownie. We know this was a LONG time ago—heck, the word “chronic” still only had one definition (and it had nothing to do with pot), but it’s important to understand the past in order to appreciate the present.
Made with hemp grown in Europe, PlusCBD Oil is tested in a state-of-the-art in-house laboratory for CBD levels; these findings are then validated by a third-party lab, which also tests to ensure that all Plus CBD Oil products are free of pesticides, fungicides, plant growth regulators, and residual solvents. A third lab uses advanced testing methods to ensure that all batches are free of heavy metals.
After seasonal harvests of specific cultivars, these high-CBD hemp crops are put through a specialized solvent-free extraction process to yield a hemp oil that is naturally high in cannabidiol. This pure hemp extract is then tested for safety, quality, and cannabinoid content before being exported to our processing facilities in the United States. Importing any cannabis or hemp product into the United States is a complicated and serious task, so we leave nothing to chance before our high-CBD hemp oil makes its journey across the Atlantic Ocean.

Today, the purest form of cannabidiol (CBD) available is an isolate. High-quality isolates test at 99-percent pure CBD and are still a relatively new product on the market. If you are new to the recent developments in the world of medicinal cannabinoids, using products like isolates might seem risky. After all, isolates look nothing like the original hemp material they came from.


The truth of the matter is that there is nothing wrong with either side of the CBD argument. There are two sides to every story, and in this case, there are benefits to each type of product. Less-processed CBD products aren’t any more natural than hemp-derived CBD isolates. They both come from the same wholly natural plant matter, but the major difference between the two is the amount of refinement.

"The data supporting efficacy and dosing are specific to one product: Epidiolex," Bonn-Miller says. "That's not necessarily translatable to 'Joe Bob's CBD Blend.'" A CBD extract you buy online or in a dispensary will almost certainly have less CBD in it, he explains, and will contain other cannabinoids—meaning that it will work differently and will need to be dosed differently. "This is not to say that 'Joe Bob's CBD Blend' definitely isn't going to be effective for pediatric epilepsy, but it means that we need to study it before we know."


As with supplements, the FDA does not review CBD products before they hit the shelves. At this time, CBD oil quality is not regulated in most states. Only states that have legalized marijuana for adult use have regulated laboratory testing for CBD sold in dispensaries. Currently, these states are Colorado, Washington, Oregon, Alaska, California, Maine, Massachusetts, and Nevada, as well as Washington D.C.

BioCBD+ uses a full spectrum hemp extract.  Most CBD companies are using an isolate version of CBD.  With an isolated, single molecule, one misses out on much of the synergistic heading properties vs. taking in the whole plant. We are only interested in serving whole plant formulations. This is called the “entourage effect”. BioCBD+ does indeed contain all the cannabinoids and terpenes (as nature intended) and is completely legal to order and use no matter where you are.”  ~Ben Greenfield
Along with its better-known counterpart, THC (delta-9-tetrahydrocannabinol, the chemical that produces the marijuana high), CBD is one of more than 400 compounds found in the oils of cannabis plant species, which include marijuana and hemp. Unlike THC, CBD will not make you high. That said, this doesn’t mean CBD is not at all psychoactive, as many assert, says Jahan Marcu, Ph.D., director of experimental pharmacology and behavior at the International Research Center on Cannabis and Mental Health in New York City: “CBD does change cognition. It affects mood, which is why people take it for anxiety. And some find that it makes them more alert.”
Also referred to as a full-spectrum extract, whole plant hemp extract contains all of the available benefits within the hemp material. By keeping all of the plant components, whole plant hemp extract benefits from the synergistic properties between the components. Scientists have found that plant components interact with one another to create an enhanced effect (compared to the component alone).
There is a lot of confusion out there. Both industrial hemp & marijuana are separate strains of the cannabis plant (hemp is c. sativa and marijuana can be either other strains of c. sativa or c. indica–marijuana has much, much more THC than hemp, which has little-to-none). The site is reviewing only CBD oils made from industrial hemp (more expensive from flower, cheaper & weaker from seeds & stalks) because those are the only kinds of CBD oil one can buy in all 50 states anywhere (not just licensed dispensaries), whether the state allows recreational weed, medical marijuana with an official cannabis ID card, or no marijuana whatsoever for any purpose.
Royal Queen Seeds CBD Oil offers a convenient, discreet and quick way to dose yourself with a bit of CBD, no matter your situation or where you are. All of our CBD oil is created using organically grown hemp sourced from right here in Europe, extracted using the latest CO² techniques. It means our oil is 100% natural, offering pure and strong CBD. All you need to do as drop you dose under your tongue or in your food, and away you go!

Kat’s Naturals offers five non-THC tinctures of varying concentrations: Heal and Naked (1,500mg), Balance (750mg), Metabolize (500mg), and Relax (300mg). All five tinctures are available in 5mL to 30mL containers, which can sustain users anywhere from five days to four weeks, depending on their dosage. Kat’s Naturals tinctures are derived from 99% pure fat soluble CBD isolate and pose no risk for yielding positive results on drug tests. For best results, Kat’s Naturals recommends ingesting three to five drops under the tongue and holding them in place for 60 seconds.
Third-party testing: Once a CBD oil is manufactured, CBD oil companies will often submit their products for third-party tests, which are conducted by non-company personnel to ensure the product is safe for public consumption and meets quality standards.CBD oils should always be accompanied with information about third-party tests; best practice is to avoid oils that do not supply these details.

CBD Topical cream

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